Version 4 (September 2007) introduced a new automation system and new VST3 format plug-ins version 5 (July 2010) added new tools for ADR and sound design and version 6 (September 2013) included new loudness metering and a new mixing console. It was the first version of the software to support the AAF file format. Version 3 of Nuendo was released in 2005, shortly after the sale of Steinberg to the Japanese multinational corporation and conglomerate, Yamaha. Version 2 followed in 2003, introducing multiple aspects of functionality previously found in the SX version of Steinberg's other DAW, Cubase, at the time. The first version of Nuendo was released by Steinberg in the year 2000.

The package is aimed at audio and video post-production market segments (marketed as an 'Advanced Audio Post-Production System', in contrast to Steinberg's other DAW software, Cubase, which is marketed as an 'Advanced Music Production System' ), but also contains optional modules that can be used for multiple multimedia creation and audio sequencing. Nuendo is a digital audio workstation (DAW) developed by Steinberg for music recording, arranging, editing and post-production.

Nuendo update